Quassinoids in Brucea javanica are potent stimulators of lipolysis in adipocytes
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چکیده
منابع مشابه
Phytochemical and antimalarial screening of Brucea javanica plant extracts
The leaf, root, and stem extracts of Brucea javanica were screened for phytochemical properties and antimalarial activity, after extractions with various organic solvents. Qualitative analysis of the phytochemical constituents showed the presence of the following secondary metabolites: terpenoids, saponins, flavonoids, steroids, phenols, glycosides, alkaloids, and anthraquinones. The extracts s...
متن کاملEvaluation of Antidiabetic and Antioxidant Properties of Brucea javanica Seed
The ethanol extract of B. javanica seed was fractionated with solvents of different polarities and tested for antioxidant activities by several assays including DPPH radical scavenging activity, ferric reducing antioxidant power (FRAP), ferrous ion chelating activity (FCA), and nitric oxide radical scavenging activity (NORSA) along with their polyphenolic contents. Antidiabetic activity was eva...
متن کاملChemical components, pharmacological properties, and nanoparticulate delivery systems of Brucea javanica
Brucea javanica has demonstrated a variety of antitumoral, antimalarial, and anti- inflammatory properties. As a Chinese herbal medicine, Brucea javanica is mainly used in the treatment of lung and gastrointestinal cancers. Pharmacological research has identified the main antitumor components are tetracyclic triterpene quassinoids. However, most of these active components have poor water solubi...
متن کاملAdiponectin Inhibits Lipolysis in Mouse Adipocytes
OBJECTIVE Adiponectin is an adipocyte-derived hormone that sensitizes insulin and improves energy metabolism in tissues. This study was designed to investigate the direct regulatory effects of adiponectin on lipid metabolism in adipocytes. RESEARCH DESIGN AND METHODS Basal and hormone-stimulated lipolysis were comparatively analyzed using white adipose tissues or primary adipocytes from adipo...
متن کاملExtracellular nucleotides are potent stimulators of human hematopoietic stem cells in vitro and in vivo.
Although extracellular nucleotides support a wide range of biologic responses of mature blood cells, little is known about their effect on blood cell progenitor cells. In this study, we assessed whether receptors for extracellular nucleotides (P2 receptors [P2Rs]) are expressed on human hematopoietic stem cells (HSCs), and whether activation by their natural ligands, adenosine triphosphate (ATP...
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ژورنال
عنوان ژورنال: Fitoterapia
سال: 2019
ISSN: 0367-326X
DOI: 10.1016/j.fitote.2019.104250